Unique ID: LM0021
Study ID: Lundgren 2009
Pubmed ID: 19015662
Database Version: 5/17/2023
Title: Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss
Publication Year: 2009
Journal: International Journal of Obesity
Primary study aim: To evaluate the rate of remission of metabolic syndrome (Met Syn) among patients undergoing a brief, low-calorie lifestyle change weight loss intervention and to compare the baseline characteristics of patients who were remitted and not remitted from Met Syn at post-treatment.
Study Design: single-arm intervention trial
What lifestyle pillars were studied? Diet/nutrition, Physical activity
For diet/nutrition studies, what was the dietary pattern studied? weight loss
For physical activity studies, what was the activity studied? Other: walking
What was the study's setting? outpatient department (not community)
Please select the population(s) studied: adults (18-54 yrs), older adults (55+ yrs)
What is the mean age of the study population? 53
What was the age range of the study population? NR
What was the mean BMI of the study population (kg/m2)? 37.2
What was the BMI range of the study population (kg/m2)? NR
What is the health status of the study population? obese, metabolic syndrome
Sex (% male): 19.4
Int: Study blindness: not applicable
Int: Study randomization: not applicable
Int: Study duration (numeric only): 15
Int: Study duration (select corresponding units): weeks
Int: Sample size: 36
Int: Sample size reported is: Analyzed (main outcome)
Int: What was the intervention used in this study (1)? The weight loss intervention combined dietary, exercise and behavioral guidance with a low-calorie diet based largely on meal replacement products during the first half of the program.
Int: What was the comparator(s) used in this study (1)? None
Study outcome 1: weight loss
Outcome group 1: weight/adiposity
Study outcome 2: waist circumference
Outcome group 2: weight/adiposity
Study outcome 3: blood pressure
Outcome group 3: cardiovascular
Study outcome 4: triglycerides
Outcome group 4: cardiovascular
Study outcome 5: HDL cholesterol
Outcome group 5: cardiovascular
Study outcome 6: fasting blood glucose
Outcome group 6: type 2 diabetes/blood glucose
Key conclusion: In a community population, metabolic syndrome (Met Syn) responds to weight loss through a low-calorie lifestyle intervention, for some patients, however, the recommended 10% weight loss may not be enough for Met Syn remission.