Unique ID: LM0092
Study ID: Aakre 2020
Pubmed ID: 32986994
Database Version: 5/17/2023
Title: Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention
Publication Year: 2020
Journal: Clinical Biochemistry
Primary study aim:
The relative effects of Roux-en-Y gastric bypass surgery (GBS) and intensive lifestyle intervention (ILI) on subclinical myocardial
injury the activity of the cardiac natriuretic system, and systemic inflammation remain unclear
Secondary aims (if applicable): NR
Study Design: other clinical trial
What lifestyle pillars were studied? Diet/nutrition, Physical activity
For diet/nutrition studies, what was the dietary pattern studied? Other: Low Calorie
Please select the population(s) studied: adults (18-54 yrs), older adults (55+ yrs)
What is the mean age of the study population? 44 (intensive-lifestyle intervention), 42 (gastric by-pass surgery)
What was the age range of the study population? NR
What was the mean BMI of the study population (kg/m2)? 41.6 (intensive-lifestyle intervention), 45.7 (gastric bypass surgery)
What was the BMI range of the study population (kg/m2)? NR
What is the health status of the study population? obese
Sex (% male): 34.35
Int: Study blindness: not blinded
Int: Study randomization: not randomized
Int: Study duration (numeric only): 59
Int: Study duration (select corresponding units): weeks
Int: Sample size: 131
Int: Sample size reported is: Analyzed (main outcome)
Int: What was the intervention used in this study (1)? Intensive lifestyle intervention: low-calorie diet, physical activity/supervised training sessions, education
Int: What was the comparator(s) used in this study (1)? 7-week low-calorie diet (900 kcal/day) followed by gastric bypass surgery
Study outcome 1: BMI
Outcome group 1: weight/adiposity
Study outcome 2: concentrations of cardiac troponin T (cTnT)
Outcome group 2: cardiovascular
Study outcome 3: N-terminal pro-B-type natriuretic peptide (NT-proBNP)
Outcome group 3: cardiovascular
Study outcome 4: C-reactive protein (CRP)
Outcome group 4: cardiovascular
Study outcome 5: carotid-femoral pulse wave velocity (cf PWV)
Outcome group 5: cardiovascular
Study outcome 6: Weight loss
Outcome group 6: weight/adiposity
Key conclusion: Compared to ILI, GBS was associated with reduced subclinical myocardial injury and systemic inflammation, and enhancement of the cardiac natriuretic peptide system. The biomarker changes were predominantly mediated by weight loss.