Unique ID: LM0127
Study ID: Zou 2022
Pubmed ID: 35523754
Database Version: 5/17/2023
Title: Diabetes remission after a lifestyle-medicine intervention on type 2 diabetes in lean and obese Chinese subjects: a prospective study
Publication Year: 2022
Journal: Annals of Palliative Medicine
Primary study aim:
The efficacy and safety of lifestyle-medicine intervention were assessed and compared between lean and obese Chinese
subjects with T2DM.
Study Design: single-arm intervention trial
What lifestyle pillars were studied? Diet/nutrition, Physical activity, Social connection, Use of risky substances
For diet/nutrition studies, what was the dietary pattern studied? Other: Initiating a low-carbohydrate (contributing by 35–40% to calorie intake) diet for the first month (gradual transition to a normal diet for the next 5 months).
Please select the population(s) studied: adults (18-54 yrs), older adults (55+ yrs)
What is the mean age of the study population? 57.51
What was the age range of the study population? 47-67
What was the mean BMI of the study population (kg/m2)? 21.85
What was the BMI range of the study population (kg/m2)? 19.61-24.09
What is the health status of the study population? overweight, obese, type 2 diabetes, cardiovascular disease
Sex (% male): 56
Int: Study blindness: not applicable
Int: Study randomization: not randomized
Int: Study duration (numeric only): 6
Int: Study duration (select corresponding units): months
Int: Sample size: 125
Int: What was the intervention used in this study (1)? stopping anti-diabetic therapy and alcohol, step-wise introduction of a lifestyle-medicine diet and exercise intervention
Int: What was the intervention used in this study (2)? []
Int: What was the intervention used in this study (3)? []
Int: What was the comparator(s) used in this study (1)? []
Study outcome 1: Weight/BMI
Outcome group 1: weight/adiposity
Study outcome 2: A1C
Outcome group 2: Other: glucose control & insulin metabolism
Study outcome 3: FPG, 2hPG
Outcome group 3: Other: c322988c-251d-46bf-af68-6d1fe1378758
Study outcome 4: HOMA-IS, HOMA-IR, HOMA-B
Outcome group 4: Other: dcff053e-a410-4892-8ed5-028744fbeec9
Study outcome 5: ALT, AST
Outcome group 5: gastrointestinal
Study outcome 6: TG, TC, HDL, LDL
Outcome group 6: cardiovascular
Study outcome 7: BUN
Outcome group 7: Other: renal
Study outcome 8: Cr
Outcome group 8: Other: renal
Key conclusion: Lifestyle-medicine interventions may have increased effectiveness in controlling mild T2DM as compared with the oral antidiabetic-based treatment, unexpectedly, there seems to be no further improvement in lean relative to obese patients. Three in five subjects could achieve diabetes remission through the lifestyle-medicine intervention regardless of whether their BMI was below or above 25.